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人脐带血中的非主要组织相容性复合体限制杀伤细胞：在补充重组白细胞介素-2的培养物中的产生及细胞毒性活性

Non-major histocompatibility complex-restricted killer cells in human cord blood: generation and cytotoxic activity in recombinant interleukin-2-supplemented cultures.

作者信息

Malygin A M, Timonen T

机构信息

Department of Pathology, University of Helsinki, Finland.

出版信息

Immunology. 1993 Jul;79(3):506-8.

PMID:7691729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1421970/
Abstract

Interleukin-2 (IL-2)-induced generation of non-major histocompatibility complex (MHC)-restricted killer cells among human cord blood lymphocytes (CBL) was investigated. After 1 week in culture with recombinant (r)IL-2 and human serum (HuSer), the cytotoxicity of CBL against K562 and COLO cells greatly exceeded the cytotoxicity of cultured adult peripheral blood lymphocytes. Culturing of CBL with rIL-2 and HuSer led to preferable generation of CD56+ cells. After 1 month in culture, the number and frequency of CD56+ cells had increased by more than 50 and nine times, respectively. The generation of CD56+ cells in CBL cultures may at least partially be explained by their comparatively strong expression of the IL-2 receptor (IL-2R) beta-chain (p75).

摘要

研究了白细胞介素-2（IL-2）诱导人脐血淋巴细胞（CBL）产生非主要组织相容性复合体（MHC）限制性杀伤细胞的情况。在用重组（r）IL-2和人血清（HuSer）培养1周后，CBL对K562和COLO细胞的细胞毒性大大超过培养的成人外周血淋巴细胞的细胞毒性。用rIL-2和HuSer培养CBL可导致CD56+细胞的优先产生。培养1个月后，CD56+细胞的数量和频率分别增加了50倍和9倍以上。CBL培养物中CD56+细胞的产生至少部分可以通过它们相对较强地表达IL-2受体（IL-2R）β链（p75）来解释。

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本文引用的文献

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A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).一种由单克隆抗体（HNK-1）识别的人自然杀伤细胞和杀伤细胞的分化抗原。
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Human newborns are deficient in natural killer activity.人类新生儿的自然杀伤活性不足。
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