Kaplan J, Shope T C, Bollinger R O, Smith J
J Clin Immunol. 1982 Oct;2(4):350-5. doi: 10.1007/BF00915078.
The peripheral blood natural killer (NK) activity of newborns was found to be significantly less than that of adults. In mixing experiments newborn cells inhibited adult NK activity in only one of nine instances. Interferon treatment in vitro increased newborn NK activity to an even greater degree than adult NK activity. These findings imply that diminished newborn NK activity is due not to inhibitory cells or lack of pre-NK cells but rather to deficient in vivo activation of pre-NK cells. This deficiency may be a major factor in the increased susceptibility of newborns to certain virus infections.
研究发现，新生儿外周血自然杀伤（NK）细胞活性显著低于成年人。在混合实验中，新生儿细胞仅在9例中的1例中抑制了成年人的NK细胞活性。体外干扰素治疗使新生儿NK细胞活性的增加程度甚至超过了成年人的NK细胞活性。这些发现表明，新生儿NK细胞活性降低并非由于抑制性细胞或前NK细胞缺乏，而是由于前NK细胞在体内的激活不足。这种不足可能是新生儿对某些病毒感染易感性增加的一个主要因素。
