Nigam S K, Karnik A B, Chattopadhyay P, Lakkad B C, Venkaiah K, Kashyap S K
National Institute of Occupational Health, Meghani Nagar, Ahmedabad, India.
Int Arch Occup Environ Health. 1993;65(1 Suppl):S193-6. doi: 10.1007/BF00381339.
365 individuals exposed to hexachlorocyclohexane (HCH) during its manufacture were studied and compared with 146 controls. These 502 cases were divided into five groups on the basis of serum total HCH levels. Exposure was mainly through skin. Results indicate that neurological symptoms reported were due to recent exposure to HCH and were related to the intensity of exposure. ECG abnormalities were seen in exposed cases. A significant positive correlation to liver related enzymes gamma GT, LAP and Alp. P was observed. beta-globulins significantly increased along with an increase in total HCH. Changes in IgM levels were similar as observed in IgA. Remarkably high concentration of HCH residues were found in the serum samples of all exposed workers. beta-HCH contributed more than 80% of the total HCH built up. Presence of circulating immune complexes was also detected in representative samples. Further, repeated biological monitoring was advised to be carried out among such workers exposed to HCH, to evaluate signs of severe health impairment in them.
对365名在六氯环己烷（HCH）制造过程中接触过该物质的个体进行了研究，并与146名对照者进行了比较。这502个病例根据血清总HCH水平分为五组。接触主要通过皮肤。结果表明，报告的神经症状是由于近期接触HCH所致，且与接触强度有关。在接触者中观察到心电图异常。观察到与肝脏相关酶γ-GT、LAP和Alp.P呈显著正相关。随着总HCH的增加，β-球蛋白显著升高。IgM水平的变化与IgA的观察结果相似。在所有接触工人的血清样本中发现了极高浓度的HCH残留。β-HCH占累积总HCH的80%以上。在代表性样本中还检测到循环免疫复合物的存在。此外，建议对接触HCH的此类工人进行反复的生物监测，以评估他们严重健康损害的迹象。
