Devereux R B, de Simone G, Ganau A, Koren M J, Roman M J
Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021.
J Cardiovasc Pharmacol. 1993;21 Suppl 2:S38-44. doi: 10.1097/00005344-199321002-00007.
Recent research indicates that the level of left ventricular (LV) mass, commonly measured by echocardiography, reflects the combined effects of a variety of factors involved in the pathophysiology of hypertension, including obesity, blood pressure responses to everyday activity, high sodium intake and blood viscosity, the volume work load of the heart, and genetic factors predisposing to hypertension. Prospective studies indicate that LV mass is a stronger predictor of subsequent morbid events and death than blood pressure or other conventional risk factors except age. Preliminary findings of close relations between LV mass and arterial disease and between the change in LV mass during antihypertensive treatment and subsequent events contribute to explaining the strong predictive value of LV mass. Further research is needed to clarify the biologic basis of these observations and to determine whether stratification of hypertensive patients based on their level of LV mass can improve the treatment of hypertension.
近期研究表明，通常通过超声心动图测量的左心室（LV）质量水平反映了高血压病理生理学中多种因素的综合作用，这些因素包括肥胖、日常活动时的血压反应、高钠摄入和血液粘度、心脏的容量工作负荷以及易患高血压的遗传因素。前瞻性研究表明，除年龄外，LV质量比血压或其他传统危险因素更能预测随后的发病事件和死亡。LV质量与动脉疾病之间以及降压治疗期间LV质量变化与随后事件之间密切关系的初步研究结果，有助于解释LV质量的强大预测价值。需要进一步研究以阐明这些观察结果的生物学基础，并确定根据LV质量水平对高血压患者进行分层是否能改善高血压的治疗。
