Thomson M L, Pavia D, Jones C J, McQuiston T A
Thorax. 1975 Dec;30(6):669-73. doi: 10.1136/thx.30.6.669.
The mucolytic efficacy of S-carboxymethylcysteine has been assessed in a double-blind crossover trial in 16 patients with chronic obstructive bronchitis. No significant difference was found between drug and placebo after four or seven days' treatment in the rate of clearance of secretions from the lung. This was measured by external counting of previously inhaled polystyrene tracer particles tagged with technetium-99m (99mTc). Lateral scans across the right chest after inhaling the aerosol showed equal penetration of particles towards the periphery of the lung in drug and placebo runs; this indicated that the airways had not been cleared of mucus by the drug. There was no significant difference between drug and placebo runs in the number of coughs or the weight and radioactive content of sputum voided or raised at the end of the run by chest percussion and postural drainage. Ventilatory capacity was not significantly changed nor was there any subjective improvement in the patients as a result of taking the drug.
在一项针对16例慢性阻塞性支气管炎患者的双盲交叉试验中，评估了S-羧甲基半胱氨酸的黏液溶解功效。在治疗4天或7天后，通过对先前吸入的用锝-99m（99mTc）标记的聚苯乙烯示踪颗粒进行体外计数来测量肺分泌物清除率，结果发现药物组与安慰剂组之间无显著差异。吸入气雾剂后对右胸进行的侧位扫描显示，在使用药物和安慰剂的试验中，颗粒向肺周边的渗透程度相同；这表明药物并未清除气道中的黏液。在咳嗽次数、通过胸部叩击和体位引流在试验结束时咳出或咳出的痰液重量及放射性含量方面，药物组与安慰剂组之间无显著差异。通气能力没有显著变化，服用药物后患者也没有任何主观改善。
