人唾液中的免疫反应性P物质。慢性疼痛的一种可能标志物。

Immunoreactive substance P in human saliva. A possible marker of chronic pain.

作者信息

Parris W C, Sastry B V, Kambam J R, Naukam R J, Johnson B W

机构信息

Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2125.

出版信息

Ann N Y Acad Sci. 1993 Sep 20;694:308-10. doi: 10.1111/j.1749-6632.1993.tb18373.x.

DOI:10.1111/j.1749-6632.1993.tb18373.x

PMID:7692800

Abstract

In all patients and volunteers, the levels of immunoreactive SP measured in saliva were about 100 times higher than the levels measured in plasma. SP per mg protein was consistently lower in both plasma and saliva of chronic pain patients than in healthy volunteers. These findings suggest that a simple noninvasive objective method of determining SP in saliva may become useful in the evaluation and treatment of chronic pain.

摘要

在所有患者和志愿者中，唾液中测得的免疫反应性P物质（SP）水平比血浆中测得的水平高约100倍。慢性疼痛患者血浆和唾液中每毫克蛋白质的SP含量始终低于健康志愿者。这些发现表明，一种简单的非侵入性客观测定唾液中SP的方法可能在慢性疼痛的评估和治疗中有用。