Parris W C, Kambam J R, Naukam R J, Rama Sastry B V
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Anesth Analg. 1990 Jan;70(1):63-7. doi: 10.1213/00000539-199001000-00010.
Substance P, a neuropeptide associated with pain perception, is widely distributed in the central nervous system and is decreased in the cerebrospinal fluid of chronic pain patients as compared with that of healthy human volunteers. In this study, we have demonstrated the presence of immunoreactive substance P in saliva and further, that both saliva and plasma levels of immunoreactive substance P are lower in patients with chronic low back pain than in healthy human volunteers. To our knowledge, this is the first time that substance P has been identified in human saliva. These findings, together with the noninvasive nature of saliva collection, suggest that substance P in saliva may be useful as an alternative neurochemical correlate of chronic low back pain when collection of cerebrospinal fluid and plasma samples for substance P analysis is unacceptable or inappropriate.
P物质是一种与疼痛感知相关的神经肽，广泛分布于中枢神经系统，与健康志愿者相比，慢性疼痛患者脑脊液中的P物质含量降低。在本研究中，我们已证实在唾液中存在免疫反应性P物质，此外，慢性下腰痛患者唾液和血浆中的免疫反应性P物质水平均低于健康志愿者。据我们所知，这是首次在人类唾液中鉴定出P物质。这些发现，连同唾液采集的非侵入性，表明当采集脑脊液和血浆样本用于P物质分析不可接受或不合适时，唾液中的P物质可能作为慢性下腰痛的一种替代神经化学相关指标。
