Agro A, Stanisz A M
Molecular Virology and Immunology Program, McMaster University, Hamilton, Ontario, Canada.
Reg Immunol. 1993 Mar-Apr;5(2):120-6.
Several neuropeptides have recently been shown to affect various aspects of the inflammatory process. Among these, the neuropeptide substance P possesses a host of immune modifying actions, which include the enhancement of lymphocyte activity, macrophage function, and neutrophil chemotaxis. The role of substance P during inflamed states has, as yet, not been fully described. Here, in T. spiralis-infected mice, we parallel increased levels of substance P both locally, (the gut) and peripherally (serum) with decreased lymphocyte responsiveness. Upon the introduction of in vivo antisubstance P antibody during the infection, levels of substance P, gastrointestinal inflammation, and lymphocyte proliferation are significantly restored to baseline (noninfected) levels. These findings suggest that the neuropeptide substance P plays an important role in promoting inflammation. It also offers the basis for future pharmacological interventions.
最近有研究表明，几种神经肽会影响炎症过程的各个方面。其中，神经肽P物质具有多种免疫调节作用，包括增强淋巴细胞活性、巨噬细胞功能和中性粒细胞趋化性。P物质在炎症状态下的作用尚未得到充分描述。在此，在感染旋毛虫的小鼠中，我们发现局部（肠道）和外周（血清）P物质水平升高的同时，淋巴细胞反应性降低。在感染期间引入体内抗P物质抗体后，P物质水平、胃肠道炎症和淋巴细胞增殖显著恢复到基线（未感染）水平。这些发现表明，神经肽P物质在促进炎症中起重要作用。这也为未来的药物干预提供了依据。
