Patel D D, Haynes B F
Department of Medicine, Duke University Arthritis Center, Durham, NC.
Semin Immunol. 1993 Aug;5(4):282-92. doi: 10.1006/smim.1993.1032.
During stem cell migration to the thymus, intrathymic maturation of T cells, and emigration of mature T cells out of the thymus, intercellular interactions of developing T cells with a myriad of cell types are required for normal T cell development. Intercellular interactions of T cell precursors with endothelial cells, thymic epithelial cells, fibroblasts, thymic macrophages and dendritic cells are all mediated by adhesion molecules on immature T cells binding to ligands on thymic microenvironment cells. While many receptor-ligand interactions that are important in intrathymic T cell development are known, the adhesion molecules that are important for migration of T cell precursors to the thymus and for emigration of mature thymocytes from the thymus are poorly understood. An emerging concept is that select adhesion molecules at discrete stages of T cell maturation participate in and regulate the complex processes of T cell development.
在干细胞迁移至胸腺、T细胞在胸腺内成熟以及成熟T细胞迁出胸腺的过程中，发育中的T细胞与多种细胞类型之间的细胞间相互作用是正常T细胞发育所必需的。T细胞前体与内皮细胞、胸腺上皮细胞、成纤维细胞、胸腺巨噬细胞和树突状细胞之间的细胞间相互作用均由未成熟T细胞上的黏附分子与胸腺微环境细胞上的配体结合介导。虽然许多在胸腺内T细胞发育中起重要作用的受体-配体相互作用已为人所知，但对于T细胞前体迁移至胸腺以及成熟胸腺细胞迁出胸腺而言重要的黏附分子却了解甚少。一个新出现的概念是，T细胞成熟离散阶段的特定黏附分子参与并调节T细胞发育的复杂过程。
