Pincelli C, Fantini F, Giannetti A
Institute of Dermatology, University of Modena, Italy.
Dermatology. 1993;187(3):153-8. doi: 10.1159/000247232.
Neuropeptides (NP) are protein compounds contained both in the central and peripheral nervous system. They can be antidromically released from sensory nerves and are implicated in the so-called neurogenic inflammation. They also exert a number of functions within the immune system and are thought to act as trophic as well as mitogenic substances. Several NP have been detected in human skin by immunohistochemical and radioimmunological techniques, and recent reports have demonstrated that NP could be involved in the mechanisms of certain dermatoses. The involvement of NP in either physiological or pathophysiological skin conditions is discussed. Moreover, a few questions, which still need to be addressed, are raised, and future directions this field of research should take are outlined.
神经肽（NP）是存在于中枢和外周神经系统中的蛋白质化合物。它们可从感觉神经逆向释放，并与所谓的神经源性炎症有关。它们在免疫系统中也发挥多种功能，被认为具有营养和促有丝分裂物质的作用。通过免疫组织化学和放射免疫技术已在人类皮肤中检测到几种神经肽，最近的报告表明神经肽可能参与某些皮肤病的发病机制。本文讨论了神经肽在生理或病理生理皮肤状况中的作用。此外，还提出了一些仍需解决的问题，并概述了该研究领域未来应采取的方向。
