Peros-Golubicić T
University Hospital for Pulmonary Diseases Jordanovac, Zagreb.
Acta Med Croatica. 1993;47(1):15-8.
The plasma neutrophil elastase levels are elevated in sarcoidosis as the author reported earlier. This study looks at the prognostic value of the plasma neutrophil elastase levels in 29 patients with lung sarcoidosis; in 18 (61.3%) the levels were elevated (167 +/- 154 microg/L); healthy controls had values in the range from 32 to 56 microg/L. Most of the patients (86.2%) had lung parenchymal sarcoidosis, i.e. radiologic stage II and III. The frequency of increased BAL neutrophils in the high plasma elastase group was higher than in the low elastase group of sarcoidosis patients, but the difference did not reach a statistical significance. The mean follow-up period was 13.5 (range 6-30) months. The patients with elevated plasma neutrophil elastase levels did not show any difference in comparison with the group with the levels within normal limits in view of the results of the lung functional parameters (FVC, FEV1, DLCO, and paO2) or the chest radiographic imaging. Neither group showed statistically significant changes in the lung function tests and both groups showed a complete or nearly complete resolution of the chest radiologic findings in the follow-up period. The measurement of plasma leukocyte elastase levels showed no prognostic value in sarcoidosis patients examined.
正如作者之前所报道的，结节病患者血浆中性粒细胞弹性蛋白酶水平升高。本研究观察了29例肺结节病患者血浆中性粒细胞弹性蛋白酶水平的预后价值；其中18例（61.3%）水平升高（167±154μg/L）；健康对照者的值在32至56μg/L范围内。大多数患者（86.2%）患有肺实质结节病，即放射学分期为II期和III期。高血浆弹性蛋白酶组结节病患者支气管肺泡灌洗中性粒细胞增加的频率高于低弹性蛋白酶组，但差异未达到统计学意义。平均随访期为13.5（范围6 - 30）个月。就肺功能参数（FVC、FEV1、DLCO和PaO2）或胸部影像学检查结果而言，血浆中性粒细胞弹性蛋白酶水平升高的患者与水平在正常范围内的组相比没有任何差异。两组在肺功能测试中均未显示出统计学上的显著变化，且两组在随访期胸部影像学表现均完全或几乎完全缓解。在所检查的结节病患者中，血浆白细胞弹性蛋白酶水平的测量没有显示出预后价值。
