Thayer R E, Singer M F, Fanning T G
Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Gene. 1993 Nov 15;133(2):273-7. doi: 10.1016/0378-1119(93)90651-i.
Nucleotide sequences near the 5' ends of some long interspersed elements-1 (LINE-1) from Homo sapiens (L1Hs) are undermethylated in cell lines which produce a L1Hs-encoded protein. In contrast, these sequences are methylated in cell lines with little or no detectable L1Hs expression. The fact that the 5' end of L1Hs is differentially methylated in cells exhibiting different levels of L1Hs expression suggests that the methylation state of this region plays a role in L1Hs expression.
来自智人的一些长散布元件1（L1Hs）5'端附近的核苷酸序列，在产生L1Hs编码蛋白的细胞系中甲基化不足。相比之下，这些序列在几乎没有或无法检测到L1Hs表达的细胞系中是甲基化的。L1Hs的5'端在表现出不同水平L1Hs表达的细胞中存在差异甲基化，这一事实表明该区域的甲基化状态在L1Hs表达中起作用。
