Sandberg M A, Miller S, Gaudio A R
Berman-Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston 02114.
Invest Ophthalmol Vis Sci. 1993 Nov;34(12):3477-80.
To determine whether fellow eyes with normal visual acuity of patients with unilateral neovascular age-related macular degeneration (AMD) have retinal malfunction.
Foveal cone electroretinograms (ERGs) were recorded from fellow eyes with visual acuities of 20/25 or better of 73 patients with unilateral neovascular AMD and from 28 normal volunteers of comparable age. Responses were elicited with a 4 degrees stimulus flickering at 42 Hz presented by a stimulator-ophthalmoscope.
The study eyes of the patients were found to have foveal cone ERGs that, on average, were normal in amplitude but delayed in implicit (peak) time after adjustment of the data for age, sex, iris pigmentation, and refractive error by multiple linear regression. Based on all subjects, amplitude declined with increasing age and was smaller in eyes with darker irides; implicit time increased with increasing age.
These findings suggest that fellow eyes with normal visual acuity of patients with unilateral neovascular AMD tend to have foveal cones that are normal in number but that function abnormally. In addition, foveal cone ERG amplitude should be adjusted for both age and iris pigmentation and implicit time should be adjusted for age when assessing retinal function of elderly patients.
确定单侧新生血管性年龄相关性黄斑变性（AMD）患者对侧视力正常的眼睛是否存在视网膜功能障碍。
对73例单侧新生血管性AMD患者对侧视力为20/25或更好的眼睛以及28名年龄相仿的正常志愿者进行了中央凹视锥细胞视网膜电图（ERG）记录。通过刺激检眼镜以42Hz闪烁的4度刺激诱发反应。
通过多元线性回归对年龄、性别、虹膜色素沉着和屈光不正数据进行调整后，发现患者的研究眼中央凹视锥细胞ERG平均振幅正常，但隐含（峰值）时间延迟。基于所有受试者，振幅随年龄增长而下降，虹膜较暗的眼睛振幅较小；隐含时间随年龄增长而增加。
这些发现表明，单侧新生血管性AMD患者对侧视力正常的眼睛往往中央凹视锥细胞数量正常，但功能异常。此外，在评估老年患者的视网膜功能时，中央凹视锥细胞ERG振幅应根据年龄和虹膜色素沉着进行调整，隐含时间应根据年龄进行调整。
