Hermonat P L, Daniel R W, Shah K V
Department of Immunology and Infectious Diseases, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205.
Sex Transm Dis. 1992 Jul-Aug;19(4):203-5. doi: 10.1097/00007435-199207000-00004.
Vaginal spermicides are effective contraceptive, and are also capable of inactivating many sexually transmitted pathogens by their detergent effect on bacterial cell membranes and viral envelopes. A 5% concentration of nonoxynol-9, the most frequently used active ingredient of spermicides, was tested for its ability to reduce the transforming activity of bovine papillomavirus type 1 (BPV-1), and the infectivity of BK virus (BKV) and cytomegalovirus (CMV). Nonoxynol-9 markedly reduced the infectivity of CMV, an enveloped virus, but did not significantly affect the activity of the nonenveloped viruses BPV-1 and BKV. Papillomavirus infections are strongly implicated in the etiology of cervical cancer. The reported protective effect of vaginal spermicides against cervical cancer is very likely not mediated by direct inactivation of papillomaviruses by the spermicide.
阴道杀精剂是有效的避孕药物，并且还能够通过其对细菌细胞膜和病毒包膜的去污剂作用来灭活许多性传播病原体。对杀精剂最常用的活性成分——5%浓度的壬苯醇醚-9，测试了其降低1型牛乳头瘤病毒（BPV-1）的转化活性以及BK病毒（BKV）和巨细胞病毒（CMV）感染性的能力。壬苯醇醚-9显著降低了包膜病毒CMV的感染性，但对无包膜病毒BPV-1和BKV的活性没有显著影响。乳头瘤病毒感染与宫颈癌的病因密切相关。所报道的阴道杀精剂对宫颈癌的保护作用很可能不是通过杀精剂对乳头瘤病毒的直接灭活来介导的。
