一些具有杀精活性的化合物的体外活性定量分析。

Quantification of the in vitro activity of some compounds with spermicidal activity.

作者信息

Chantler E, Fisher H, Solanki S, Elstein M

机构信息

Department of Obstetrics and Gynaecology, University Hospital of South Manchester.

出版信息

Contraception. 1992 Dec;46(6):527-36. doi: 10.1016/0010-7824(92)90117-c.

DOI:10.1016/0010-7824(92)90117-c

PMID:1283567

Abstract

The in vitro spermicidal activity of the commonly used surfactant spermicides and the antiseptic chlorhexidine, were quantified in a statistically reproducible manner, using donor semen and image capture analysis. The spermicidal activity was expressed as the ED50 under defined assay conditions. Using these parameters, the order of spermicidal activity was: Menfegol > nonoxynol-9 approximately benzalkonium chloride > sodium docusate > chlorhexidine. These differences were statistically significant.

摘要

使用供体精液和图像捕获分析，以统计学上可重复的方式对常用表面活性剂杀精剂和防腐剂洗必泰的体外杀精活性进行了定量。杀精活性在规定的试验条件下表示为半数有效剂量（ED50）。根据这些参数，杀精活性顺序为：门贝醇＞壬苯醇醚-9≈苯扎氯铵＞多库酯钠＞洗必泰。这些差异具有统计学意义。