Terenghi G, Riveros-Moreno V, Hudson L D, Ibrahim N B, Polak J M
Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
J Neurol Sci. 1993 Aug;118(1):34-7. doi: 10.1016/0022-510x(93)90242-q.
The presence of nitric oxide synthase in spinal cord and dorsal root ganglia was investigated by immunohistochemistry using antibodies against the constitutive neuronal form of nitric oxide synthase (NOS). NOS immunoreactivity was present in both man and rat with similar distribution, being present in primary sensory neurons of dorsal root ganglia and their afferent terminals in dorsal horn of spinal cord. NOS immunoreactive interneurons were found in the superficial layer of the dorsal horn, around the central canal and in the intermediolateral cell column. NOS immunoreactivity was also present in numerous motoneurons in the ventral horn. The widespread distribution of NOS in both sensory and motor nervous system is indicative of the involvement of nitric oxide in different neural functions.
采用抗组成型神经元型一氧化氮合酶（NOS）抗体，通过免疫组织化学方法研究了脊髓和背根神经节中一氧化氮合酶的存在情况。人和大鼠均存在一氧化氮合酶免疫反应性，且分布相似，存在于背根神经节的初级感觉神经元及其在脊髓背角的传入终末。在脊髓背角浅层、中央管周围和中间外侧细胞柱中发现了一氧化氮合酶免疫反应性中间神经元。在腹角的许多运动神经元中也存在一氧化氮合酶免疫反应性。一氧化氮合酶在感觉和运动神经系统中的广泛分布表明一氧化氮参与了不同的神经功能。
