Meucci G, Rossi G, Bettini R, Montanaro D, Gironelli L, Voci L, Bianchi F
Institute of Clinical Neurology, University of Pisa, Italy.
J Neurol Sci. 1993 Aug;118(1):73-8. doi: 10.1016/0022-510x(93)90248-w.
Cerebrospinal fluid and serum levels of albumin, immunoglobulin G and alpha 2-macroglobulin were determined by laser nephelometer in various pathological conditions: Guillain-Barré syndrome amyotrophic lateral sclerosis, lumbar disc herniation. These proteins are different due to their molecular weight, spacial conformation, CSF and serum concentrations and their CSF/serum quotient reflects the status of the blood-brain barrier. In the subjects group comparisons, albumin quotient and IgG quotient show a significant differentiations. The linear regression of albumin quotient compared to alpha 2-macroglobulin quotient behaves differently in the individual groups. The protein CSF/serum quotients are helpful in distinguishing the causes of alterations in the blood-brain barrier.
采用激光散射比浊法测定了多种病理状况下（吉兰-巴雷综合征、肌萎缩侧索硬化症、腰椎间盘突出症）脑脊液和血清中白蛋白、免疫球蛋白G及α2-巨球蛋白的水平。这些蛋白质因其分子量、空间构象、脑脊液和血清浓度的不同而各异，其脑脊液/血清商数反映了血脑屏障的状态。在各受试者组比较中，白蛋白商数和免疫球蛋白G商数存在显著差异。白蛋白商数与α2-巨球蛋白商数的线性回归在各个组中的表现有所不同。脑脊液/血清蛋白质商数有助于区分血脑屏障改变的原因。
