Sergueeva O A, Fedorov N B, Reymann K G
Department of Neurophysiology, Institute of Neurobiology, Magdeburg, Germany.
Neuropharmacology. 1993 Sep;32(9):933-5. doi: 10.1016/0028-3908(93)90150-2.
(RS)-alpha-methyl-4-carboxyphenylglycine (MCPG), a compound which selectively antagonizes metabotropic glutamate receptors (mGlu-R), presents the LTP of field excitatory postsynaptic potentials (fEPSP) as well as the tetanus-induced increase in AMPA-evoked responses (fPRs) in the CA1 region of hippocampal slices. This effects of MCPG provide evidence for the involvement of mGlu-Rs in mechanisms underlying the postsynaptic maintenance of LTP, which appears to be mediated, at least partially, by an increase in sensitivity and/or number of postsynaptic AMPA receptors.
（RS）-α-甲基-4-羧基苯甘氨酸（MCPG）是一种选择性拮抗代谢型谷氨酸受体（mGlu-R）的化合物，它可抑制海马切片CA1区的场兴奋性突触后电位（fEPSP）的长时程增强（LTP）以及强直刺激诱导的AMPA诱发反应（fPRs）的增加。MCPG的这种作用为mGlu-Rs参与LTP突触后维持机制提供了证据，这一机制似乎至少部分是由突触后AMPA受体的敏感性和/或数量增加介导的。
