Bordi F, Ugolini A
Glaxo Research Laboratories, Verona, Italy.
Eur J Pharmacol. 1995 Feb 6;273(3):291-4. doi: 10.1016/0014-2999(94)00756-w.
The effects of two competitive metabotropic glutamate (mGlu) receptor antagonists, (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG) and (S)-4-carboxylphenylglycine (4CPG), were studied on long-term potentiation in the dentate gyrus of rats under urethane anaesthesia. Intracerebroventricular (i.c.v.) injection of MCPG or 4CPG 30 min prior to tetanic stimulation of the perforant path in rats did not affect the induction of long-term potentiation measured by extracellular recording. As a control, i.c.v. injections of the NMDA receptor antagonist, dl(-)-2-amino-5-phosphonopentanoic (dl-AP5), effectively blocked long-term potentiation. These results suggest that the mGlu receptor subtype blocked by MCPG and 4CPG is not involved in long-term potentiation in the dentate gyrus.
研究了两种竞争性代谢型谷氨酸（mGlu）受体拮抗剂，（RS）-α-甲基-4-羧基苯基甘氨酸（MCPG）和（S）-4-羧基苯基甘氨酸（4CPG）对在乌拉坦麻醉下大鼠齿状回长时程增强的影响。在大鼠对穿通通路进行强直刺激前30分钟，脑室内（i.c.v.）注射MCPG或4CPG不影响通过细胞外记录测量的长时程增强的诱导。作为对照，脑室内注射NMDA受体拮抗剂，dl（-）-2-氨基-5-膦酰基戊酸（dl-AP5），有效阻断了长时程增强。这些结果表明，被MCPG和4CPG阻断的mGlu受体亚型不参与齿状回的长时程增强。
