体外循环期间不同形式抑肽酶的作用
Effects of different forms of aprotinin during cardiopulmonary bypass.
作者信息
De Bakker A, De Hert S, Vlaeminck R, Delrue G, Govaerts E, Vermeyen K
机构信息
Department of Anesthesia, University Hospital Antwerp, Belgium.
出版信息
Acta Anaesthesiol Belg. 1993;44(2):45-51.
Effects of two different forms of aprotinin on postoperative blood loss and need for blood replacement were compared in patients undergoing cardiac surgery. One group (n = 46) received 2.10(6) KIA aprotinin (Trasylol), the other group (n = 46) received 2.10(6) PIU aprotinin (Iniprol). Blood loss during the first 12 hours postoperatively was similar (704 +/- 59 ml and 701 +/- 93 ml respectively). Amount of postoperatively transfused blood, fresh frozen plasma, platelets, plasma expanders and fluids was comparable in both groups. Effects of cardiopulmonary bypass on aPTT, PTT, fibrinogen and platelet count were also similar.
在接受心脏手术的患者中，比较了两种不同形式的抑肽酶对术后失血量和输血需求的影响。一组（n = 46）接受2.10(6) KIA抑肽酶（抑肽酶注射液），另一组（n = 46）接受2.10(6) PIU抑肽酶（抑肽酶原）。术后前12小时的失血量相似（分别为704±59毫升和701±93毫升）。两组术后输注的血液、新鲜冰冻血浆、血小板、血浆扩容剂和液体量相当。体外循环对活化部分凝血活酶时间（aPTT）、部分凝血活酶时间（PTT）、纤维蛋白原和血小板计数的影响也相似。
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