Schlesinger M, Yodfat Y, Rabinowitz R, Bronner S, Kark J D
Hubert H. Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Adv Exp Med Biol. 1993;335:247-54. doi: 10.1007/978-1-4615-2980-4_34.
The aim of the present study was to assess the effect of daily psychosocial stress on the human immune system. We tested 38 couples living in a communal settlement (kibbutz) under similar economic and social conditions, sharing similar housing, nutrition and health care. They were tested repeatedly over a two year period for a number of psychosocial parameters including demoralization, social support, family cohesion, adaptational hardiness and hostility. In parallel, the natural killer "NK" cell system was analysed for distinctive markers and for cytotoxic activity. The proportion of CD16+ lymphocytes was found to correlate with cytotoxic NK activity in both men and women. In contrast, the proportion of CD57+ cells correlated with that of CD16+ cells only in women while in men only the CD57+CD8-lymphocytes subset correlated with CD16+ cells. For each individual tested, the values of NK activity and NK markers obtained in tests carried out more than a year apart showed a striking correlation. In males, NK cytotoxicity correlated with hostility but was negatively correlated with family cohesion, adaptability and hardiness. The level of CD16+ and CD57+ cells correlated positively with demoralization in males only. Changes in the level of NK activity and in the level of CD16+ cells occurring in husbands during the observation period correlated positively with changes in demoralization and negatively with changes in family cohesion and adaptability. The results indicate that daily psychological stress and low family function may enhance the NK system, and that this response may differ between the sexes.
本研究的目的是评估日常心理社会压力对人类免疫系统的影响。我们测试了38对生活在类似经济和社会条件下的集体定居点（基布兹）的夫妇，他们共享相似的住房、营养和医疗保健。在两年时间里，对他们多次进行测试，涉及一系列心理社会参数，包括士气低落、社会支持、家庭凝聚力、适应能力和敌意。同时，分析自然杀伤（NK）细胞系统的独特标志物和细胞毒性活性。结果发现，CD16+淋巴细胞的比例在男性和女性中均与NK细胞毒性活性相关。相比之下，CD57+细胞的比例仅在女性中与CD16+细胞的比例相关，而在男性中只有CD57+CD8-淋巴细胞亚群与CD16+细胞相关。对于每个接受测试的个体，相隔一年以上进行的测试中获得的NK活性和NK标志物的值显示出显著的相关性。在男性中，NK细胞毒性与敌意相关，但与家庭凝聚力、适应能力和坚韧度呈负相关。CD16+和CD57+细胞的水平仅在男性中与士气低落呈正相关。在观察期内，丈夫们的NK活性水平和CD16+细胞水平的变化与士气低落的变化呈正相关，与家庭凝聚力和适应能力的变化呈负相关。结果表明，日常心理压力和低家庭功能可能会增强NK系统，而且这种反应可能存在性别差异。
