Urso C, Paglierani M, Bondi R
Institute of Pathological Anatomy and Histology, University of Florence, Italy.
Am J Dermatopathol. 1993 Oct;15(5):435-40. doi: 10.1097/00000372-199310000-00004.
Seven cases of sweat-gland carcinomas showing eccrine ductal differentiation (ductal carcinomas) are presented. The tumors had a variable histological appearance, but were basically characterized by the following histological elements: (a) tubular structures, sometimes cystic or having a "tadpole" appearance; (b) solid islands of squamous, basaloid, or clear cells; (c) periodic acid-Schiff-positive endoluminal and/or intracellular material; and (d) infiltrating growth. Immunocytochemically, tumor cells were positive for keratin and negative for actin. Endoluminal material contained carcinoembryonic antigen in five of seven cases. Although it is not yet clear whether carcinomas exhibiting eccrine ductal differentiation may represent a specific histotype or a group encompassing several distinct clinicopathological entities, the histological analysis of the cases suggested that the wide spectrum of their histological appearances may be due to variable grades of differentiation.
本文报告了7例显示小汗腺导管分化的汗腺癌（导管癌）。这些肿瘤具有多种组织学表现，但基本特征如下：（a）管状结构，有时呈囊性或呈“蝌蚪”状；（b）鳞状、基底样或透明细胞的实性岛状结构；（c）过碘酸希夫染色阳性的管腔内和/或细胞内物质；（d）浸润性生长。免疫细胞化学显示，肿瘤细胞角蛋白阳性，肌动蛋白阴性。7例中有5例管腔内物质含有癌胚抗原。虽然目前尚不清楚表现为小汗腺导管分化的癌是代表一种特定的组织学类型还是一组包含几种不同临床病理实体的肿瘤，但对这些病例的组织学分析表明，其广泛的组织学表现可能是由于分化程度不同所致。
