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在硅橡胶盘上形成生物膜生长的类鼻疽伯克霍尔德菌对头孢他啶和复方新诺明的耐药性。

Resistance of Pseudomonas pseudomallei growing as a biofilm on silastic discs to ceftazidime and co-trimoxazole.

作者信息

Vorachit M, Lam K, Jayanetra P, Costerton J W

机构信息

Ramathibodi Hospital, Bangkok, Thailand.

出版信息

Antimicrob Agents Chemother. 1993 Sep;37(9):2000-2. doi: 10.1128/AAC.37.9.2000.

DOI:10.1128/AAC.37.9.2000
PMID:7694545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC188109/
Abstract

We have examined the resistance of Pseudomonas pseudomallei biofilm cells to ceftazidime and cotrimoxazole. A large number of these biofilm cells remained viable at 12 and at 24 h, except in the biofilm treated with 200 times the MIC of ceftazidime. The inherent resistance of P. pseudomallei biofilms to conventional antibiotics may explain the lack of success in the treatment of the chronic manifestations of this bacterial infection.

摘要

我们已经检测了类鼻疽假单胞菌生物膜细胞对头孢他啶和复方新诺明的耐药性。除了用200倍头孢他啶最低抑菌浓度处理的生物膜外，大量此类生物膜细胞在12小时和24小时时仍具有活力。类鼻疽假单胞菌生物膜对传统抗生素的固有耐药性可能解释了该细菌感染慢性表现的治疗为何未取得成功。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/986e/188109/2f9f418aa597/aac00031-0301-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/986e/188109/2f9f418aa597/aac00031-0301-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/986e/188109/2f9f418aa597/aac00031-0301-a.jpg

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