Schmitz-Feuerhake I, Huchzermeyer H, Reblin T
Acta Hepatogastroenterol (Stuttg). 1975 Jun;22(3):150-8.
The technique applying the inhalation of radioactive rare gase is a new method to determine the specific blood flow of the liver. After inhalation of 133Xe, the course of activity is registered above liver and spleen as well as in the exspirated air. The perfusion is calculated from the resulting wash-out curves. The average value in healthy persons is 91 +/- 15 ml/100 g min. The reproducibility is 5 +/- 1%. The xenon wash-out is delayed in cirrhotic livers; the blood flow is significantly decreased and amounts to an average of 45 ml/100 g min. A delayed wash-out of xenon was also found in major fatty livers due to the high affinity of xenon to fat. The dependence of the partition coefficient on the fat content was investigated by Kitani and Winkler in homogenized liver tissue of different fat content. The question arises whether these in vitro findings can be transferred to in vivo wash-out curves. We therefore carried out first investigations on patients of known content of fat of the liver, applying a 85MKr-133 Xe-double measurement. According to results which have been achieved up to now, sufficient accuracy can only be obtained up to a fat content of 10%.
应用放射性稀有气体吸入的技术是一种测定肝脏特定血流量的新方法。吸入133Xe后，记录肝脏、脾脏上方以及呼出气体中的活性变化过程。根据所得的洗脱曲线计算灌注量。健康人的平均值为91±15毫升/100克·分钟。重现性为5±1%。肝硬化肝脏中氙的洗脱延迟；血流量显著降低，平均为45毫升/100克·分钟。由于氙对脂肪的高亲和力，在重度脂肪肝中也发现氙的洗脱延迟。Kitani和Winkler在不同脂肪含量的匀浆肝组织中研究了分配系数对脂肪含量的依赖性。问题是这些体外研究结果能否转化为体内洗脱曲线。因此，我们对已知肝脏脂肪含量的患者进行了首次研究，采用85MKr - 133Xe双测量法。根据目前已取得的结果，只有在脂肪含量达到10%之前才能获得足够的准确性。
