Loening-Baucke V, Yamada T
Dept. of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242.
Electroencephalogr Clin Neurophysiol. 1993 Nov-Dec;88(6):447-52. doi: 10.1016/0168-5597(93)90033-l.
The afferent pathways from the rectum can be stimulated and studied after mechanical distention of the rectum. We studied the rectum-brain axis in 24 healthy young adults. The rectum was stimulated with a rectal balloon using inflation volumes of 10 ml and 30 ml air at a stimulation frequency of 0.167 Hz. Additional studies were carried out with 20 ml distention volumes, random stimulation frequency, and stimulation rates of 0.08 Hz and 0.017 Hz. We found two different cortical EPs. An early onset EP was present in 21 of the 24 subjects. P1 latency shortened significantly with increasing distention volumes, but peak amplitudes did not change significantly with larger distention volumes. A late onset EP was present in all subjects with NI latency of 210 +/- 15 msec, PI latency of 316 +/- 24 msec, and NII latency of 444 +/- 34 msec. The different EPs could be due to stimulation of two different visceral afferent pathways which are present in the same individual, due to stimulation of two different fiber populations or due to simultaneous stimulation of afferents in surrounding structures. EP recording after rectal stimulation might be useful in future studies of patients with abnormal rectal sensation.
在直肠受到机械扩张后，可刺激并研究来自直肠的传入通路。我们对24名健康的年轻成年人的直肠-脑轴进行了研究。使用直肠球囊，以0.167 Hz的刺激频率，分别用10 ml和30 ml空气的充气量刺激直肠。还进行了其他研究，采用20 ml的扩张量、随机刺激频率以及0.08 Hz和0.017 Hz的刺激率。我们发现了两种不同的皮质诱发电位。24名受试者中有21名出现了早期诱发电位。随着扩张量增加，P1潜伏期显著缩短，但随着更大的扩张量，峰值幅度没有显著变化。所有受试者均出现了晚期诱发电位，NI潜伏期为210±15毫秒，PI潜伏期为316±24毫秒，NII潜伏期为444±34毫秒。不同的诱发电位可能是由于刺激了同一个体中存在的两种不同的内脏传入通路、两种不同的纤维群，或者是由于同时刺激了周围结构中的传入神经。直肠刺激后的诱发电位记录可能在未来对直肠感觉异常患者的研究中有用。
