Katzenstein A L, Gordon L P, Oliphant M, Swender P T
Department of Pathology, State University of New York at Syracuse.
Am J Surg Pathol. 1995 Apr;19(4):439-47.
We describe nine infants with a rare form of interstitial lung disease that is characterized by marked alveolar septal thickening, striking alveolar pneumocyte hyperplasia, and an alveolar exudate containing numerous macrophages and foci of eosinophilic debris. Primitive mesenchymal cells predominate within the widened alveolar septa; inflammatory cells are scant. This entity occurs exclusively in infants and very young children and differs from other types of interstitial pneumonia occurring in either children or adults. The histologic findings suggest that it may reflect slowly resolving or recurrent pneumonia superimposed on immature or abnormally developed lungs. The term chronic pneumonitis of infancy was chosen to reflect the unique occurrence of this lesion in young children and to emphasize its distinction from adult forms of interstitial pneumonia.
我们描述了9例患有罕见间质性肺疾病的婴儿，其特征为显著的肺泡间隔增厚、明显的肺泡上皮细胞增生，以及含有大量巨噬细胞和嗜酸性粒细胞碎片灶的肺泡渗出物。在增宽的肺泡间隔内，原始间充质细胞占主导；炎症细胞稀少。这种疾病仅发生于婴儿和非常年幼的儿童，与儿童或成人的其他类型间质性肺炎不同。组织学表现提示，它可能反映了叠加于未成熟或发育异常肺脏上的缓慢消散或复发性肺炎。选择“婴儿慢性肺炎”这一术语是为了反映该病变在幼儿中的独特发生情况，并强调其与成人型间质性肺炎的区别。
