De Rezende N A, Dias M B, Campolina D, Chavez-Olortegui C, Diniz C R, Amaral C F
Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Am J Trop Med Hyg. 1995 Mar;52(3):277-80. doi: 10.4269/ajtmh.1995.52.277.
Enzyme-linked immunosorbent assays for detection of Tityus serrulatus venom antigen and of horse anti-T. serrulatus venom antibodies were carried out before antivenom treatment and at 1, 6, 12, and 24 hr after antivenom therapy in 18 patients with systemic manifestations following T. serrulatus scorpion sting. Increased levels of circulating venom antigens were detected in the patients before antivenom treatment, but were no longer detected 1 hr after specific antivenom therapy. High titers of antivenom persisted for at least 24 hr after treatment with antivenom. The evolution of clinical and laboratory manifestations of envenoming showed that vomiting and local pain decreased within 1 hr and hyperglycemia was no longer detected 12 hr after antivenom therapy. The cardiorespiratory manifestations disappeared 6-24 hr after the administration of antivenom and all patients recovered completely. This study demonstrates the efficacy of antivenom therapy in neutralizing circulating venom antigens and supports the prompt administration of a potent antivenom to patients with systemic manifestations of envenoming.
对18例有锯尾蝎蜇伤后出现全身症状的患者，在抗蛇毒血清治疗前以及抗蛇毒血清治疗后1、6、12和24小时进行了酶联免疫吸附试验，以检测锯尾蝎毒液抗原和马抗锯尾蝎毒液抗体。在抗蛇毒血清治疗前检测到患者循环毒液抗原水平升高，但在特异性抗蛇毒血清治疗1小时后不再检测到。抗蛇毒血清治疗后高滴度抗蛇毒血清至少持续24小时。中毒的临床和实验室表现演变显示，抗蛇毒血清治疗1小时内呕吐和局部疼痛减轻，抗蛇毒血清治疗12小时后不再检测到高血糖。抗蛇毒血清给药后6 - 24小时心肺症状消失，所有患者完全康复。本研究证明了抗蛇毒血清疗法在中和循环毒液抗原方面的有效性，并支持对有中毒全身症状的患者迅速给予有效的抗蛇毒血清。
