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在疟疾高度流行地区，短期使用奎宁与抗生素联合治疗成年疟疾患者疗效显著。

High efficacy of short-term quinine-antibiotic combinations for treating adult malaria patients in an area in which malaria is hyperendemic.

作者信息

Metzger W, Mordmüller B, Graninger W, Bienzle U, Kremsner P G

机构信息

International Research Laboratory, Albert-Schweitzer-Hospital, Lambaréné, Gabon.

出版信息

Antimicrob Agents Chemother. 1995 Jan;39(1):245-6. doi: 10.1128/AAC.39.1.245.

DOI:10.1128/AAC.39.1.245
PMID:7695315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162517/
Abstract

In a randomized trial, a three-dose quinine monotherapy was compared with short-term combination regimens of quinine-clindamycin and quinine-doxycycline for treating adult Gabonese patients with Plasmodium falciparum malaria. In quinine-treated patients, only 38% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.

摘要

在一项随机试验中，将三剂量奎宁单一疗法与奎宁-克林霉素及奎宁-多西环素的短期联合疗法进行比较，用于治疗成年加蓬恶性疟原虫疟疾患者。在接受奎宁治疗的患者中，最终只有38%被治愈。相比之下，接受任何一种联合疗法治疗后，超过90%的患者被治愈。

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本文引用的文献

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Curing of chloroquine-resistant malaria with clindamycin.用克林霉素治愈耐氯喹疟疾
Am J Trop Med Hyg. 1993 Nov;49(5):650-4. doi: 10.4269/ajtmh.1993.49.650.
2
Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon.克林霉素与氯喹或奎宁联合使用，对加蓬儿童的非复杂性恶性疟原虫疟疾是一种有效的治疗方法。
J Infect Dis. 1994 Feb;169(2):467-70. doi: 10.1093/infdis/169.2.467.
3
Comparison of micronized halofantrine with chloroquine-antibiotic combinations for treating Plasmodium falciparum malaria in adults from Gabon.微粉化卤泛群与氯喹-抗生素联合用药治疗加蓬成年人恶性疟原虫疟疾的比较。
Am J Trop Med Hyg. 1994 Jun;50(6):790-5. doi: 10.4269/ajtmh.1994.50.790.
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[Use of tetracycline and quinine combination in the treatment of Plasmodium falciparum malaria].四环素与奎宁联合用于治疗恶性疟原虫疟疾
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Trans R Soc Trop Med Hyg. 1990 Jan-Feb;84(1):54. doi: 10.1016/0035-9203(90)90379-s.
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