Santré C, Georges H, Jacquier J M, Leroy O, Beuscart C, Buguin D, Beaucaire G
Intensive Care and Infectious Diseases Unit, Lille University Medicine School, Tourcoing, France.
Antimicrob Agents Chemother. 1995 Jan;39(1):264-7. doi: 10.1128/AAC.39.1.264.
In this study, concentrations of amikacin in blood and bronchial secretions of 10 patients with mechanical ventilation for acute respiratory failure due to pneumonia were measured. One-half of the patients received amikacin twice daily, and the others received once-daily administration. Concentrations in bronchial secretions of the patients treated twice daily ranged from 3 to 4 mg/liter, i.e., they were similar to those in previously published reports. Peak concentrations in bronchial secretions occurred between 3 and 4 h after the onset of infusion, and they reached 4.8 +/- 2.6 mg/liter on day 1 and 4.0 +/- 2.7 mg/liter on day 3. For the patients treated with amikacin once daily, concentrations in bronchial secretions were more than twofold higher, above 8 mg/liter for 12 h. Peak concentrations in bronchial secretions occurred between 3 and 4 h after the onset of infusion and reached 13.6 +/- 9.3 mg/liter on day 1 and 10.4 +/- 3.5 mg/liter on day 3. These concentrations are higher than the MICs for less sensitive bacterial strains, such as Acinetobacter spp. and Pseudomonas aeruginosa.
在本研究中，测定了10例因肺炎导致急性呼吸衰竭而行机械通气患者血液和支气管分泌物中的阿米卡星浓度。一半患者每日接受两次阿米卡星治疗，其余患者接受每日一次给药。每日接受两次治疗的患者支气管分泌物中的浓度范围为3至4毫克/升，即与先前发表的报告中的浓度相似。支气管分泌物中的峰值浓度在输注开始后3至4小时出现，第1天达到4.8±2.6毫克/升，第3天达到4.0±2.7毫克/升。对于每日接受一次阿米卡星治疗的患者，支气管分泌物中的浓度高出两倍多，12小时内高于8毫克/升。支气管分泌物中的峰值浓度在输注开始后3至4小时出现，第1天达到13.6±9.3毫克/升，第3天达到10.4±3.5毫克/升。这些浓度高于对较不敏感细菌菌株如不动杆菌属和铜绿假单胞菌的最低抑菌浓度。
