Ahlström B, Chelminska-Bertilsson M, Thompson R A, Edebo L
Department of Clinical Bacteriology, Göteborg University, Sweden.
Antimicrob Agents Chemother. 1995 Jan;39(1):50-5. doi: 10.1128/AAC.39.1.50.
A new category of amphiphilic hydrolyzable quaternary ammonium compounds with rapid and high levels of antimicrobial activity was studied. The compounds, alkanoylcholines with hydrocarbon chains of 10 to 14 carbon atoms, are hydrolyzed by butyrylcholine esterase, which is present in human serum and mucosal membranes. The hydrolysis products are common components of human metabolism. Alkanoylcholines were tested and found to be active against gram-negative and gram-positive bacteria as well as yeasts. The microbicidal activities of the alkanoylcholines were comparable to the activities of the stable quaternary ammonium compounds of corresponding chain length and increased with an increasing number of carbon atoms. The compounds were also found to be hydrolyzed by enzymes present in certain microorganisms. The degradation was achieved after reaching the microbicidal effect.
研究了一类具有快速且高效抗菌活性的新型两亲性可水解季铵化合物。这些化合物是具有10至14个碳原子烃链的烷酰胆碱，可被存在于人体血清和粘膜中的丁酰胆碱酯酶水解。水解产物是人体新陈代谢的常见成分。对烷酰胆碱进行了测试，发现它们对革兰氏阴性菌、革兰氏阳性菌以及酵母菌均有活性。烷酰胆碱的杀菌活性与相应链长的稳定季铵化合物的活性相当，且随着碳原子数的增加而增强。还发现这些化合物可被某些微生物中存在的酶水解。降解在达到杀菌效果后实现。
