Li T K, Lumeng L, McBride W J, Murphy J M
Indiana University School of Medicine, Indianapolis.
Alcohol Alcohol. 1994 Nov;29(6):697-700.
Through selective breeding, rat lines exhibiting high and low alcohol drinking preference have been developed as useful animal models for studying the neurobiological basis of alcohol-seeking behavior. The identified differences between lines in neurotransmitter functioning allows the evaluation of receptor agonist/antagonist compounds that might be efficacious in the treatment of alcohol craving and dependence.
通过选择性育种，已培育出表现出高饮酒偏好和低饮酒偏好的大鼠品系，作为研究觅酒行为神经生物学基础的有用动物模型。品系之间在神经递质功能方面已确定的差异，使得评估可能对治疗酒精渴望和依赖有效的受体激动剂/拮抗剂化合物成为可能。
