Pietinen P
National Public Health Institute, Department of Nutrition, Helsinki, Finland.
Ann Med. 1994 Dec;26(6):465-8. doi: 10.3109/07853899409148370.
Both animal and human data suggest that polyunsaturated fatty acids of n-6 and n-3 series may play a role in blood pressure regulation. The majority of dietary intervention studies have shown that changing from a high fat, low linoleic acid diet to a low fat, high linoleic acid diet lowers blood pressure. However, controlled, double-bind studies do not support the independent effect of linoleic acid. Polyunsaturated n-3 fish fatty acids lower blood pressure but only in pharmacological doses that cannot generally be recommended. The mechanisms of blood pressure regulation by n-6 and n-3 fatty acids seem to be related to prostaglandin metabolism.
动物和人类数据均表明，n-6和n-3系列的多不饱和脂肪酸可能在血压调节中发挥作用。大多数饮食干预研究表明，从高脂肪、低亚油酸饮食转变为低脂肪、高亚油酸饮食可降低血压。然而，对照双盲研究并不支持亚油酸的独立作用。多不饱和n-3鱼类脂肪酸可降低血压，但仅在通常不建议使用的药理剂量下有效。n-6和n-3脂肪酸调节血压的机制似乎与前列腺素代谢有关。
