Peters K M, Rosendahl T, Heller K D, Weigmann R, Zilkens K W
Department of Orthopaedic Surgery, Rheinisch-Westflische Technische Hochschule Aachen, Germany.
Arch Orthop Trauma Surg. 1994;114(1):53-5. doi: 10.1007/BF00454739.
Osteocalcin is a vitamin K-dependent bone protein synthesized by osteoblasts. In generalized bone disorders serum osteocalcin correlates with osteoblast activity. Bone resorption and new bone formation occur in chronic osteomyelitis, dependent on the level of inflammatory activity. In 17 patients with active chronic osteomyelitis undergoing surgery, the serum levels of osteocalcin, alkaline phosphatase and C-reactive protein were measured before and after treatment. The osteocalcin levels were within the normal range preoperatively (10.8 +/- 11.0 micrograms/l), in the early postoperative period, and at discharge. It is therefore not a helpful marker in the clinical management of this condition.
骨钙素是一种由成骨细胞合成的维生素K依赖型骨蛋白。在全身性骨疾病中，血清骨钙素与成骨细胞活性相关。慢性骨髓炎中会发生骨吸收和新骨形成，这取决于炎症活动的程度。在17例接受手术的活动性慢性骨髓炎患者中，于治疗前后测定了血清骨钙素、碱性磷酸酶和C反应蛋白水平。骨钙素水平在术前（10.8±11.0微克/升）、术后早期及出院时均在正常范围内。因此，它在这种疾病的临床管理中不是一个有用的标志物。
