Philipov J P, Pascalev M D, Aminkov B Y, Grosev C D
Department of Surgery, Faculty of Veterinary Medicine, Stara Zagora, Bulgaria.
Calcif Tissue Int. 1995 Aug;57(2):152-4. doi: 10.1007/BF00298436.
Blood biochemical indices of bone turnover were followed up for 1 month in six dogs with experimental osteomyelitis. The bone infection resulted in significant increase in parameters of bone formation (serum bone alkaline phosphatase and serum osteocalcin) and bone resorption [serum carboxyterminal telopeptide of type I collagen (i-ICTP)] as early as the end of the second week after the operation and inoculation. There was strong evidence that serum i-ICTP levels could be useful for the early diagnosis of postoperative complications in veterinary orthopedics, such as posttraumatic osteomyelitis.
对六只患有实验性骨髓炎的犬的骨转换血液生化指标进行了1个月的随访。骨感染早在手术和接种后第二周结束时就导致骨形成参数（血清骨碱性磷酸酶和血清骨钙素）和骨吸收[血清I型胶原羧基末端肽（i-ICTP）]显著增加。有强有力的证据表明，血清i-ICTP水平可用于兽医骨科术后并发症的早期诊断，如创伤后骨髓炎。
