cDNA cloning of a thromboxane A2 receptor from rat astrocytes.
作者信息
Kitanaka J, Hashimoto H, Sugimoto Y, Sawada M, Negishi M, Suzumura A, Marunouchi T, Ichikawa A, Baba A
机构信息
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
出版信息
Biochim Biophys Acta. 1995 Mar 16;1265(2-3):220-3. doi: 10.1016/0167-4889(94)00225-4.
A cDNA clone for rat thromboxane (TX) A2 receptor was obtained from cultured astrocytes. The cDNA encodes a protein of 341 amino acids with seven putative transmembrane domains. The receptor is homologous with mouse and human TXA2 receptors at 92.7% and 71.8%, respectively. Expression of messenger RNA for the receptor was examined by reverse transcriptase-polymerase chain reaction, showing ubiquitous expression in brain glial cells such as astrocytes, oligodendrocytes and microglia.
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