Baraboĭ V A, Bororov L V, Hunina L M, Maievs'ka L P
Lik Sprava. 1994 Jul-Aug(7-8):143-5.
Dibunol was administered 48 and 24 hours before the operation at a dose of 4 g using capsules of 1 g each, in lung cancer patients. Stress severity was judged from the blood content of hydrocortisone, 17-keto- and 17-ketogenic steroids in 24-h urine, the content of mid-molecular weight peptides and indicators of intoxication before the operation and at 1, 3 and 5-7 day following it. Stress-protective effect of dibunol was manifested by almost 2-fold reduction in the blood hydrocortisone, urine 17-KS and 17-KGS/24 h levels following the operation, and by return of these parameters to baseline level at day 3 (whilst without dibunal no normalization occurred even at day 5-7), as well as by an appreciable lowering of the parameters characterizing intoxication.
在肺癌患者中，手术前48小时和24小时分别服用4克双丁诺尔，每粒胶囊1克。根据氢化可的松的血含量、24小时尿液中17 - 酮类固醇和17 - 生酮类固醇、手术前及术后第1、3和5 - 7天的中分子量肽含量及中毒指标来判断应激严重程度。双丁诺尔的应激保护作用表现为术后血氢化可的松、尿17 - KS和24小时尿17 - KGS水平几乎降低了两倍，且这些参数在第3天恢复到基线水平（而未使用双丁诺尔的情况下，即使在第5 - 7天也未恢复正常），同时还表现为中毒特征参数明显降低。
