Salvagno L, Sorarú M, Leszl A, Koussis H, De Franchis G, Fiorentino M V
Divisione di Oncologia Medica, Centro Oncologico Regionale, Padova, Italy.
Leuk Lymphoma. 1994 Dec;16(1-2):177-81. doi: 10.3109/10428199409114156.
A case of secondary chronic myelogenous leukemia after successful therapy for Hodgkin's disease is reported. The patient was diagnosed as having stage IIIA Hodgkin's disease, at the age of 33. He underwent staging laparosplenectomy and was treated with radiotherapy plus chemotherapy. Forty three months after the diagnosis of Hodgkin's disease, a Philadelphia-positive chronic myelogenous leukemia developed. It required periodic chemotherapy and each time a remission, lasting several months (up to 14 months), was obtained. The disease had an unusually prolonged clinical course, and the blast crisis, of lymphoid type, occurred only 17 years later.
报告了1例霍奇金病成功治疗后发生继发性慢性粒细胞白血病的病例。患者33岁时被诊断为IIIA期霍奇金病。他接受了分期剖腹脾切除术，并接受了放疗加化疗。霍奇金病诊断后43个月，出现了费城染色体阳性的慢性粒细胞白血病。需要定期化疗，每次化疗后均获得了持续数月（最长14个月）的缓解期。该疾病的临床病程异常延长，17年后才发生淋巴样类型的原始细胞危象。
