氯丙嗪和碳酸锂对大鼠脑、肝及红细胞中超氧化物歧化酶和谷胱甘肽过氧化物酶活性的影响。
The effect of chlorpromazine and Li2CO3 on the superoxide dismutase and glutathione peroxidase activities of rat brain, liver and erythrocytes.
作者信息
Abdalla D S, Bechara E J
机构信息
Department of Clinical and Toxicological Analyses, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brasil.
出版信息
Biochem Mol Biol Int. 1994 Dec;34(6):1085-90.
The effect of the antipsychotic agents chlorpromazine (CPZ) and Li2CO3 on superoxide dismutase (SOD, EC 1.15.1.1) and glutathione peroxidase (GPx, EC 1.11.1.9) activities of brain, liver and erythrocyte of rats was investigated. The short-term treatment (7 days) either with CPZ (10 mg/kg body weight) or with Li2CO3 (2 mEq Li/kg body weight) did not affect enzymatic activities. In contrast, the long-term administration of CPZ (1 month) decreased the SOD activity in brain and erythrocytes while Li2CO3 had no effect. GPx activity and lipid peroxidation of brain and liver homogenates were not affected by either acute or chronic administration of these agents.
研究了抗精神病药物氯丙嗪（CPZ）和碳酸锂（Li2CO3）对大鼠脑、肝和红细胞中超氧化物歧化酶（SOD，EC 1.15.1.1）和谷胱甘肽过氧化物酶（GPx，EC 1.11.1.9）活性的影响。短期治疗（7天），无论是使用CPZ（10毫克/千克体重）还是Li2CO3（2毫当量锂/千克体重），均未影响酶活性。相反，长期给予CPZ（1个月）会降低脑和红细胞中的SOD活性，而Li2CO3则无此作用。这些药物的急性或慢性给药均未影响脑和肝匀浆中的GPx活性及脂质过氧化。
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