Bernstein H G, Kirschke H, Wiederanders B, Khudoerkov R M, Hinz W, Rinne A
Institute of Neurobiology and Brain Research Magdeburg, Martin-Luther-University Halle, Wittenberg, Germany.
Acta Histochem Suppl. 1992;42:19-24.
The cathepsin B, D and L were studied by immunohistochemical techniques in the human postmortem brain. The enzyme were primarily localized in neurons. Makroglial cells were seldom immunostained. It is shown that cathepsins B and D frequently occur in neuritic plaques of Alzheimer victims, thereby raising the question, whether or not cathepsin immunohistochemistry is a useful tool in the diagnosis of this disease. Furthermore, we identified certain glial cells to be immunoreactive for cathepsins in schizophrenics.
