Mrozikiewicz A
Arch Immunol Ther Exp (Warsz). 1975;23(6):795-801.
In patients with endogenous depression, imipramine exerts a regulative effect in both directions on blood pressure and pulse rate, dependent on the starting levels. In a majority of patients treated with imipramine, after 14 days blood pressure dropped and pulse rate was slowed. Remission of endogenous depression was statistically significantly more frequent in patients treated with imipramine in whom pressure and pulse rate underwent normalization. Early appearance of these effects of imipramine in patients with endogenous depression seems to be a good prognostic index.
在内源性抑郁症患者中，丙咪嗪对血压和脉搏率具有双向调节作用，这取决于起始水平。在大多数接受丙咪嗪治疗的患者中，14天后血压下降，脉搏率减慢。在血压和脉搏率恢复正常的接受丙咪嗪治疗的患者中，内源性抑郁症的缓解在统计学上更为常见。丙咪嗪对内源性抑郁症患者的这些作用早期出现似乎是一个良好的预后指标。
