Rudolf G A, Bischofs W, Blaszkiewicz F, Bremer W, Tölle R
Arzneimittelforschung. 1976;26(6):1174-7.
The effect of sleep deprivation (SD) on the altered circadian rhythm of endogenous-depressed patients has been investigated. 61 patients (39 endogenous- and 22 neurotic-depressed) with normal cardio-circulatory activities were tested: During SD-night pulse rate is less lowered in endogenous than in neurotic depression. The increase of systolic blood pressure is quicker and higher in endogenous than in neurotic depression. - Surveying the patients for 72 h (before, during and after SD), pulse rate in endogenous- and neurotic-depressed is less markedly fluctuating than in normal individuals. There is a close connection between the circadian fluctuationsof the depressive symptoms and of the pulse rates. The more SD improves depressive symptoms the more it also flattens the wave of pulse rates. - The circadian courses of systolic blood pressure in endogenous- and neurotic-depressed and in normal subjects are nearly the same. SD markedly flattens the circadian rhythm of blood pressure. In neurotic depression, SD does not clearly alter the course of pulse and blood pressure rates.
研究了睡眠剥夺（SD）对内源性抑郁症患者昼夜节律改变的影响。对61例心血管循环活动正常的患者（39例内源性抑郁症患者和22例神经性抑郁症患者）进行了测试：在睡眠剥夺期间的夜间，内源性抑郁症患者的脉搏率下降幅度小于神经性抑郁症患者。内源性抑郁症患者收缩压的升高比神经性抑郁症患者更快、更高。在对患者进行72小时（睡眠剥夺前、期间和之后）的观察中，内源性和神经性抑郁症患者的脉搏率波动不如正常个体明显。抑郁症状的昼夜波动与脉搏率之间存在密切联系。睡眠剥夺越能改善抑郁症状，就越能使脉搏率的波动趋于平缓。内源性和神经性抑郁症患者以及正常受试者的收缩压昼夜变化过程几乎相同。睡眠剥夺明显使血压的昼夜节律趋于平缓。在神经性抑郁症中，睡眠剥夺并未明显改变脉搏和血压的变化过程。
