Isaacs K R, Abbott L C
NIMH, Laboratory of Clinical Science, Bethesda, MD 20892.
Brain Res Bull. 1995;36(3):309-14. doi: 10.1016/0361-9230(94)00207-h.
The volume of the cerebellum as a whole and the volume of the molecular layer per Purkinje cell in adult tottering (tg/tg) and tottering/leaner (tg/tg(la)) mice were reduced when compared with normal age-matched wild type mice (+/+). No changes in the volume of the granule cell layer or white matter layer were detected, suggesting that the mutation effects were limited to the molecular layer of the cerebellum. The density of Purkinje cells and the total number of Purkinje cells did not vary between groups. The cerebellar and body weights were decreased in tg/tg and tg/tg(la) mice compared with +/+ mice.
与年龄匹配的正常野生型小鼠（+/+）相比，成年蹒跚小鼠（tg/tg）和蹒跚/倾斜小鼠（tg/tg(la)）的整个小脑体积以及每个浦肯野细胞的分子层体积均减小。未检测到颗粒细胞层或白质层体积的变化，这表明突变效应仅限于小脑的分子层。各组之间浦肯野细胞的密度和浦肯野细胞的总数没有差异。与+/+小鼠相比，tg/tg和tg/tg(la)小鼠的小脑重量和体重均降低。
