Solange A
F. Hoffmann-La Roche AG, Basel, Switzerland.
Chem Phys Lipids. 1995 Jan 12;75(1):51-8. doi: 10.1016/0009-3084(94)02400-Y.
The synthesis and biological activities of several glycopeptidolipids derived from muramyl dipeptide (MDP) are described. In combination with gamma interferon (INF-gamma) MDP derivatives 3c and 3d carrying glycyrrhetinic acid as rigid beta-aglycone synergise the action of the lymphokine in the release of H2O2 by activated human macrophages, while MDP derivatives 3a and 6a carrying the more flexible diphytanyl glycerol beta-aglycone inhibit it.
本文描述了几种源自胞壁酰二肽（MDP）的糖肽脂质的合成及其生物活性。与γ干扰素（INF-γ）联合使用时，以甘草次酸作为刚性β-糖苷配基的MDP衍生物3c和3d可协同淋巴因子促进活化的人巨噬细胞释放H2O2，而带有更具柔性的二植烷酰甘油β-糖苷配基的MDP衍生物3a和6a则起抑制作用。
