大鼠慢性胃溃疡中两种表型不同的B淋巴细胞（IgM高IgD低和IgM低IgD高）
Two phenotypically distinct B lymphocytes (IgMhighIgDlow and IgMlowIgDhigh) in chronic gastric ulcer in the rat.
作者信息
Ohmiya N, Ito M, Ohbayashi M, Arisawa T, Goto H, Tsukamoto Y, Hayakawa T, Asai J
机构信息
Second Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan.
出版信息
Clin Exp Immunol. 1995 Apr;100(1):151-6. doi: 10.1111/j.1365-2249.1995.tb03617.x.
We determined the kinetics and phenotypes of infiltrating B cells in gastric ulcer in the rat induced by gastric injection of acetic acid (day 0). Few B cells were found in the lesion in the early stages of ulceration. On day 40, two kinds of B cells with phenotypes of IgMhighIgDlowOX33 (CD45)+OX19 (CD5)- and IgMlowIgDhighOX33 (CD45)+OX19 (CD5)- were scattered in the granulation tissue of open ulcers, but not in the healed scar tissue. On day 180, those two kinds of B cells formed primary follicles in the granulation tissue of open ulcers, but were absent from the healed scar tissue. The IgMhighIgDlowOX33 (CD45)+OX19 (CD5)- B cell was considered to be identical to the marginal zone B cell of rat spleen. This phenotype of B cell might be associated with inflammatory process in chronic gastric ulcer.
我们测定了通过胃内注射乙酸（第0天）诱导的大鼠胃溃疡中浸润B细胞的动力学和表型。在溃疡形成的早期阶段，病变部位发现的B细胞很少。在第40天，两种表型分别为IgM高IgD低OX33（CD45）⁺OX19（CD5）⁻和IgM低IgD高OX33（CD45）⁺OX19（CD5）⁻的B细胞散在于开放性溃疡的肉芽组织中，但在愈合的瘢痕组织中未发现。在第180天，这两种B细胞在开放性溃疡的肉芽组织中形成了初级滤泡，但在愈合的瘢痕组织中不存在。IgM高IgD低OX33（CD45）⁺OX19（CD5）⁻ B细胞被认为与大鼠脾脏的边缘区B细胞相同。这种B细胞表型可能与慢性胃溃疡的炎症过程有关。
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