Spencer J, Finn T, Pulford K A, Mason D Y, Isaacson P G
Clin Exp Immunol. 1985 Dec;62(3):607-12.
B cells in normal human Peyer's patches and in primary B cell lymphomas of the stomach have been characterized in terms of their cellular morphology and their reactivity with a panel of monoclonal antibodies. A population of B cells is present in normal and malignant gut-associated lymphoid tissue which is composed of neither mantle zone cells nor germinal centre cells. In Peyer's patches these cells surround the follicles merging with the mantle zone and extending both into the dome region, infiltrating between the epithelial cells and also towards the serosa. They are intermediate in size with irregular nuclear outlines and they resemble the centrocytes in the follicle centre. They are quiescent, expressing C3b- and C3d-receptors and surface IgM but not surface IgD. These centrocytes-like cells which are not seen in the peripheral lymph nodes are identical to the B cells in the marginal zone of the spleen according to all of the criteria employed in this study.
已根据细胞形态及其与一组单克隆抗体的反应性，对正常人派尔集合淋巴结和胃原发性B细胞淋巴瘤中的B细胞进行了表征。在正常和恶性的肠道相关淋巴组织中存在一群B细胞，它们既不是套区细胞也不是生发中心细胞。在派尔集合淋巴结中，这些细胞围绕滤泡，与套区融合，并延伸至圆顶区，浸润在上皮细胞之间，也向浆膜方向延伸。它们大小中等，核轮廓不规则，类似于滤泡中心的中心细胞。它们处于静止状态，表达C3b和C3d受体以及表面IgM，但不表达表面IgD。根据本研究采用的所有标准，这些在外周淋巴结中未见的中心细胞样细胞与脾脏边缘区的B细胞相同。
