系统性硬化症患者自体混合淋巴细胞反应期间转化生长因子-β（TGF-β）的产生增加。
Enhanced production of transforming growth factor-beta (TGF-beta) during autologous mixed lymphocyte reaction of systemic sclerosis patients.
作者信息
Ota H, Kumagai S, Morinobu A, Yanagida H, Nakao K
机构信息
Second Department of Internal Medicine, School of Medicine, Kyoto University, Japan.
出版信息
Clin Exp Immunol. 1995 Apr;100(1):99-103. doi: 10.1111/j.1365-2249.1995.tb03609.x.
Systemic sclerosis (SSc) is characterized by systemic fibrosis and microvascular lesions. As TGF-beta is suggested to be related to skin fibrosis, we examined the production of TGF-beta from peripheral mononuclear cells (MNC) of SSc patients. Since anti-TGF-beta neutralizing antibody improved the defective proliferative response in autologous mixed lymphocyte reaction (AMLR) of SSc patients, TGF-beta was thought to participate in the decreased AMLR of SSc patients. Greater amounts of TGF-beta in the active as well as in the latent forms were produced during AMLR of SSc patients than that of normal subjects. It was suggested that TGF-beta excessively produced from the MNC of SSc patients might play a major role in the fibrosis of the patients during AMLR-like in vivo responses.
系统性硬化症（SSc）的特征是全身纤维化和微血管病变。由于提示转化生长因子-β（TGF-β）与皮肤纤维化有关，我们检测了SSc患者外周血单个核细胞（MNC）中TGF-β的产生情况。由于抗TGF-β中和抗体改善了SSc患者自体混合淋巴细胞反应（AMLR）中的缺陷增殖反应，因此认为TGF-β参与了SSc患者AMLR的降低。与正常受试者相比，SSc患者在AMLR过程中产生的活性和潜伏形式的TGF-β量更多。提示SSc患者MNC过度产生的TGF-β可能在类AMLR体内反应过程中对患者的纤维化起主要作用。
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