正常细胞上存在的同种异体抗原与大鼠急性髓性白血病（SAL）的肿瘤特异性移植型抗原的交叉反应性。
Cross reactivity of an alloantigen present on normal cells with the tumour-specific transplantation-type antigen of the acute myeloid leukaemia (SAL) of rats.
作者信息
Wrathmell A B, Gauci C L, Alexander P
出版信息
Br J Cancer. 1976 Feb;33(2):187-94. doi: 10.1038/bjc.1976.24.
Abstract
Resistance can be induced in the syngeneic host (August rats) to a myelogeneous leukaemia of spontaneous origin, called SAL, by immunization with allogeneic cells derived form both normal and malignant tissues obtained from the Hooded rat strain. Serological experiments support the conclusion that the antigen involved-referred to as "Ho-SAL"-has the properties of a tumour specific transplantation-type antigen for SAL cells but is a widely expressed alloantigen found in both normal and malignant cells derived from Hooded rats. Antisera to it can be raised in Wistar rats.
摘要
通过用来自带帽大鼠品系的正常和恶性组织的同种异体细胞进行免疫，可在同基因宿主（奥古斯塔大鼠）中诱导对自发起源的一种髓性白血病（称为SAL）产生抗性。血清学实验支持这样的结论，即所涉及的抗原——称为“Ho-SAL”——对SAL细胞具有肿瘤特异性移植型抗原的特性，但却是一种在来自带帽大鼠的正常和恶性细胞中广泛表达的同种异体抗原。针对它的抗血清可在Wistar大鼠中产生。
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