Sekizaki T, Takai S, Egawa Y, Ikeda T, Ito H, Tsubaki S
National Institute of Animal Health, Ibaraki, Japan.
Gene. 1995 Mar 21;155(1):135-6. doi: 10.1016/0378-1119(95)00009-u.
The nucleotide sequence of the Rhodococcus equi gene encoding the virulence-associated 15-17-kDa antigens, located on plasmid pREAT701, has been determined. The gene encodes a 19-kDa protein of 189 amino acids, with an Ala-rich leader signal sequence (SS). At least five SS peptidase cleavage sites were found in this region. The molecular diversity of 15-17-kDa antigens might be attributed to the multiple SS peptidase cleavage sites.
已确定位于质粒pREAT701上编码与毒力相关的15 - 17 kDa抗原的马红球菌基因的核苷酸序列。该基因编码一个由189个氨基酸组成的19 kDa蛋白，带有一个富含丙氨酸的前导信号序列（SS）。在该区域发现了至少五个信号肽酶切割位点。15 - 17 kDa抗原的分子多样性可能归因于多个信号肽酶切割位点。
