皮肤淋巴瘤样肉芽肿病中的爱泼斯坦-巴尔病毒

Epstein-Barr virus in cutaneous lymphomatoid granulomatosis.

作者信息

Angel C A, Slater D N, Royds J A, Nelson S N, Bleehen S S

机构信息

Department of Pathology, University of Sheffield Medical School, UK.

出版信息

Histopathology. 1994 Dec;25(6):545-8. doi: 10.1111/j.1365-2559.1994.tb01373.x.

DOI:10.1111/j.1365-2559.1994.tb01373.x

PMID:7698731

Abstract

Epstein-Barr virus (EBV) has been associated with various extra-cutaneous lymphoproliferative diseases and it has been suggested that EBV may have a similar aetiological role in the skin. In this study, 10 biopsies from 7 cases of primary cutaneous lymphomatoid granulomatosis have been analyzed, using in situ hybridisation, for the presence of EBV encoded RNAs (EBER-1 and EBER-2). Only one case showed positive staining with the EBER probes and it is concluded that, in the skin, the relationship between EBV and lymphomatoid granulomatosis is variable. The role of EBV as an etiological agent in primary cutaneous lymphomatoid granulomatosis appears less important than in primary respiratory disease.

摘要

爱泼斯坦-巴尔病毒（EBV）与多种皮肤外淋巴增殖性疾病有关，有人认为EBV在皮肤中可能具有类似的病因学作用。在本研究中，对7例原发性皮肤淋巴瘤样肉芽肿病患者的10份活检标本进行了原位杂交分析，以检测EBV编码RNA（EBER-1和EBER-2）的存在情况。只有1例标本用EBER探针染色呈阳性，由此得出结论，在皮肤中，EBV与淋巴瘤样肉芽肿病之间的关系是多变的。EBV作为原发性皮肤淋巴瘤样肉芽肿病的病原体，其作用似乎不如在原发性呼吸道疾病中那么重要。