Angel C A, Slater D N, Royds J A, Nelson S N, Bleehen S S
Department of Pathology, University of Sheffield Medical School, UK.
J Pathol. 1996 Feb;178(2):173-5. doi: 10.1002/(SICI)1096-9896(199602)178:2<173::AID-PATH428>3.0.CO;2-Y.
Epstein-Barr virus (EBV) has been associated with various extracutaneous lymphoproliferative diseases and it has been suggested that EBV may have a similar aetiological role in cutaneous T-cell lymphoma. In this study, in situ hybridization was used to investigate the presence of EBV encoded RNAs (EBER-1 and EBER-2) in 37 biopsies from 28 cases of primary cutaneous T-cell lymphoma originating from the U.K. The results showed that EBV had no demonstrable pathogenic role in the lymphomas studied, as EBER was not detected in any case.
爱泼斯坦-巴尔病毒（EBV）与多种皮肤外淋巴增殖性疾病有关，有人认为EBV在皮肤T细胞淋巴瘤中可能具有类似的病因学作用。在本研究中，采用原位杂交技术对来自英国的28例原发性皮肤T细胞淋巴瘤的37份活检标本进行检测，以研究EBV编码RNA（EBER-1和EBER-2）的存在情况。结果显示，在所研究的淋巴瘤中，EBV没有可证实的致病作用，因为在任何病例中均未检测到EBER。
